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KMID : 0191120110260101310
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Journal of Korean Medical Science
2011 Volume.26 No. 10 p.1310 ~ p.1315
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Changes in Renal Function after Different Tandem Hematopoietic Stem-cell Transplantation Approaches in Patients with Multiple Myeloma
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Kang Seok-Hui
Hwang Hyeon-Seok
Park Hoon-Suk
Sun In-O
Choi Sun-Ryoung
Chung Byung-Ha
Choi Bum-Soon
Yang Chul-Woo
Kim Yong-Soo
Min Chang-Ki
Park Cheol-Whee
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Abstract
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This study was done to observe the alteration of the estimated glomerular filtration rate (eGFR) in multiple myeloma patients according to type of tandem hematopoietic stem cell transplantation (HSCT). Forty-one patients were enrolled in this study. Twenty patients underwent autologous HSCT (auto-HSCT) and 21 patients underwent allogeneic HSCT (allo-HSCT). The changes in eGFR after the two tandem HSCT modalities were different between the two groups, according to the donor of stem cells (P = 0.016). In the auto-HSCT group, the eGFR, recorded 12 months after secondary HSCT, was significantly decreased compared with the eGFR recorded before stem cell mobilization (P = 0.005). Although there was no significant difference, the trend showed that the eGFR after allo-HSCT decreased from the previous HSCT until a month after secondary HSCT. In addition, after 6 months of secondary HSCT, the eGFR recovered to the level recorded prior to the HSCT (P = 0.062). This difference may be due to total body irradiation, a calcineurin inhibitor, or maintemance therapy. Changes in renal function would be monitored closely for these patients. The recovery of the eGFR would be a main focus for the patients treated with the total body irradiation or the calcineurin inhibitor, a progressive decline of the eGFR would be also crucial for the patients treated with maintenance therapy.
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KEYWORD
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Multiple Myeloma, Allogeneic Stem-Cell Transplantation, Autologous Stem-Cell Transplantation, Renal Function, Tandem Transplantation
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